Genesis 4:15-17

Amplified Bible

¹⁵And the Lord said to him, “^[a]Therefore, whoever kills Cain, a sevenfold vengeance [that is, punishment seven times worse] shall be taken on him [by Me].” And the Lord set a [protective] ^[b]mark (sign) on Cain, so that no one who found (met) him would kill him.^(A)

¹⁶So Cain went away from the [manifested] presence of the Lord, and lived in the land of Nod [wandering in exile], east of Eden.

¹⁷Cain knew his ^[c]wife [one of Adam’s descendants] and she conceived and gave birth to Enoch; and Cain built a city and named it Enoch, after the name of his son.

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Footnotes

Genesis 4:15 Some ancient versions read, “Not so!”
Genesis 4:15 Many commentators believe this sign not to have been like a brand on the forehead, but something awesome about Cain’s appearance that made people dread and avoid him. In the Talmud, the rabbis suggested several possibilities, including leprosy, boils, or a horn that grew out of Cain. But it was also suggested that Cain was given a pet dog to serve as a protective sign.
Genesis 4:17 The simplest explanation for the origin of Cain’s wife is that she was one of his sisters, whom Scripture does not mention specifically, but implies (5:4). It is also possible that she was a niece or more distant relative descended from the original family, but in any case it is evident that the unrecorded children of Adam and Eve married each other. This was possible because the human gene pool was at its purest with Adam and Eve, so at some point their children could begin families of their own.